7-2-04   From David Anderson DVM  Ohio State University


Assessment of the METABOLIC EFFECT OF HYDROCORTISONE on llamas before and
after feed restriction

Christopher K. Cebra, VMD, MA, MS; Susan J. Tornquist, DVM, PhD; Rebecca M.
Jester, BS; Calogero Stelletta, DVM *
Am J Vet Res 2004;65:1002-1005

 The objective of this study was to evaluate the effects of administration
of hydrocortisone on plasma concentration of insulin and serum
concentrations of glucose, triglyceride, and nonesterified fatty acids
(NEFAs) in llamas before and after feed restriction.Feed was withheld from
llamas for 8 hours. Blood samples were collected before (0 minutes) and 120,
180, 240, and 300 minutes after IV injection of hydrocortisone sodium
succinate (1 mg/kg) for determination of plasma insulin concentration and
serum concentrations of glucose, triglyceride, and NEFAs. The llamas were
then fed a limited diet (grass hay, 0.25% of body weight daily) for 21 days,
after which the experimental procedures were repeated.Compared with llamas
that were not feed-restricted, llamas after feed restriction had
significantly higher plasma insulin concentration and serum concentrations
of triglycerides and NEFAs. Feed-restricted llamas after hydrocortisone
injection had a significantly smaller increase in serum glucose
concentration, a decrease (rather than an increase) in serum concentration
of NEFAs, and no change in blood concentrations of insulin or triglycerides.
Short-acting glucocorticoid hormones did not appear to increase blood lipid
concentrations in healthy llamas, regardless of ongoing fat mobilization.
Thus, these hormones appear unlikely to be major direct contributors to
diseases such as hepatic lipidosis or hyperlipemia. Although administration
of hydrocortisone reduced serum concentration of fatty acids in
feed-restricted llamas, its use has not been evaluated in sick camelids and
cannot be considered therapeutically useful.

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