12-20-04    From David Anderson DVM  Ohio State University:


Epinephrine and Insulin

Assessment of the effects of epinephrine and insulin on plasma and serum
biochemical variables in llamas and alpacas Christopher K. Cebra, VMD, MS,
and Susan J. Tornquist, DVM, PhD *
 The objective of this research was to describe the metabolic effects of
epinephrine administration in New World camelids and investigate whether
these effects are influenced by administration of insulin. Prior to each
experiment, food was withheld from camelids for 8 hours. On each of 2
consecutive days, alpacas were administered epinephrine (10 mg/kg, IM; time
0); alpacas were randomly assigned to receive regular insulin (0.2 U/kg, IV)
immediately after epinephrine administration on one of those days. In
llamas, the experiment was performed once after administration of
epinephrine only. At 0, 30, 60, 90, 120, 150, 180, 210, and 240 minutes
after treatment, blood samples were collected and several serum or plasma
biochemical variables were assessed; in addition, plasma samples from llamas
were assessed for insulin concentrations. Data were compared between days
(alpacas only) and between time points. Administration of epinephrine induced
mobilization of glucose, triglycerides, nonesterified fatty acids, and
β-hydroxybutyrate. A small increase in endogenous insulin concentration was
detected in epinephrine-treated llamas, compared with baseline values.
Overall, insulin administration decreased, negated, or delayed the
epinephrine-associated increases in serum or plasma concentrations of
circulating energy substrates, except that it augmented the
epinephrine-associated increase in concentration of triglycerides.
Epinephrine appeared to mobilize energy substrates in camelids and hence may
be involved in the pathogenesis of disorders of glucose and fat metabolism.
Insulin appeared to antagonize most of these effects, and its administration
may have therapeutic value in camelids. (Am J Vet Res 2004;65:1692-1696)

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